USS Roosevelt (DDG 80) deployed in spring 2002, as part USS John F. Kennedy Battle Group, in support of Operation Enduring Freedom and Maritime Interdiction Operations in Mediterranean Sea and Arabian Gulf.

December 6, USS Roosevelt returned to Mayport, Fla., after a six-month underway period in support of the operations Enduring Freedom, Iraqi Freedom and the global war on terrorism.

September 8, 2005 As a precautionary measure, U.S. Navy ships homeported in Mayport got underway in anticipation of possible impacts from Tropical Storm Ophelia. The following ships are heading to sea: USS Carney (DDG 64), USS McInerney (FFG 8), USS Simpson (FFG 56), USS Samuel B. Roberts (FFG 58), USS Boone (FFG 28), USS DeWert (FFG 45), USS Roosevelt, USS The Sullivans (DDG 68), USS Vicksburg (CG 69), USS Hue City (CG 66), USS Gettysburg (CG 64), USS John L. Hall (FFG 32), USS Stephen W. Groves (FFG 29) and USS Thomas S. Gates (CG 51).

January 25, 2006 DDG 80 departed for approximately three months in support of Maritime Security Operations (MSO) and the Global War on Terrorism.

February 8, The guided-missile destroyer pulled to Souda Bay, Crete, for a routine port visit.

October 6, USS Roosevelt departed Mayport to join up with various Norfolk-based ships to cross the Atlantic Ocean for waters in and around Scotland in preparation for Neptune Warrior. Neptune Warrior is a joint military training course organized by the Joint Maritime Operational Training Staff (JMOTS) Northwood in the United Kingdom.

March 7, 2007 USS Roosevelt departerd Naval Station Mayport for a scheduled deployment.

March 31, DDG 80 pulled to Tivat, Montenegro for a brief port call. The destroyer arrived in Split, Croatia, April 2nd.

April 13, USS Roosevelt, commanded by Cmdr. John A. Carter, is currently participating in a National Atlantic Treaty Organization (NATO)-led exercise Noble Manta from April 12-22. The largest joint anti-submarine warfare exercise held annually in the Mediterranean Sea, Noble Manta 2007 involves 10 NATO countries which provide maritime patrol aircraft, surface and subsurface assets.

July 28, USS Roosevelt arrived in La Maddalena, Italy, for a voyage repair availability period.

May 11, 2008 The guided-missile destroyer is currently off the East Coast participating in Integration Strike Group Exercise with USS Iwo Jima (LHD 7) ESG.

August 28, USS Roosevelt departed homeport for a scheduled underway period, as part of the Iwo Jima Expeditionary Strike Group.

September 16, DDG 80 departed Dubrovnik, Croatia, after a four-day port visit.

November 8, The destroyer is currently conducting Maritime Security Operations in the Persian Gulf.

February 27, 2009 The Roosevelt transited the Suez Canal after completing operations in the U.S. Central Command Area of Responsibility.

March 25, USS Roosevelt returned to Mayport after a seven-month deployment to the U.S. Navy's 5th and 6th Fleet Areas of Operation. She provided support to the pirated motor vessel (M/V) Faina, the Ukrainian arms ship held hostage by Somali pirates for several months, and operated off the Horn of Africa in support of national tasking, logging two lengthy underway periods of 70 and 83 consecutive days.

May 20, DDG 80 pulled to New York City to participate in the 22nd Fleet Week New York.

October 28, USS Roosevelt entered the drydock at Atlantic Marine Shipyard in Jacksonville for a Docking Selected Restricted Availability (DSRA).

November 20, Cmdr. Robert B. Chadwick II relieved Cmdr. Stanley O. Keeve Jr. as CO of the Roosevelt during a change-of-command ceremony at the Helicopter Anti-Submarine Light Squadron Four Two (HSL-42) hangar at Naval Station Mayport.

February 4, 2010 The guided-missile destroyer departed dry-dock and returned to Mayport Naval Station.

February 11, 2011 USS Roosvelt departed Yorktown, Va., for a six-day friends and family cruise to Mayport.

March 24, DDG 80 departed homeport for a Friends and Family Day Cruise.

March 30, USS Roosevelt departed Naval Station Mayport for a scheduled deployment. The ship departed Rota, Spain, April 14 after a three-day port call and transited Suez Canal April 20.

July 1, Cmdr. Robert S. Thompson relieved Cmdr. Robert B. Chadwick II as CO of the Roosevelt during a change-of-command ceremony aboard the ship.

August 5, USS Roosevelt arrived in Victoria, Seychelles, for a six-day port visit after 113 days at sea.

October 4, The guided-missile destroyer departed Port Louis, Mauritius, after a five-day port call.

November 8, USS Roosevelt returned to Mayport after a two-day delay due to rough seas, completing the seven-month deployment in the U.S. 5th and 7th Fleet AoR.

April 30, 2012 DDG 80 departed Naval Station Mayport for sea trials after a six-month Selected Restricted Availability (SRA).