USS Annapolis (SSN 760), an "improved" Los Angeles-class submarine, was the fourth ship of the United States Navy to be named for Annapolis, Maryland, site of the United States Naval Academy. The contract to build her was awarded to the Electric Boat Division of General Dynamics Corporation in Groton, Connecticut on March 21, 1986 and her keel was laid down on June 15, 1988. She was launched on May 18, 1991 sponsored by Mrs. Myrna F. Kauderer, and commissioned on April 11, 1992, with Cmdr. Richard Servinghaus in command.

April 23, 2003 USS Annapolis entered the Portsmouth Navy Yard for a scheduled maintenance.

May 24, 2004 USS Annapolis, commanded by Cmdr. Donald E. Neubert Jr., returned to Naval Submarine Base (SUBASE) New London following eight days of sea trials and a year-long $138 million depot modernization period (DMP) at the Portsmouth Naval Shipyard (PNSY) in Kittery, Maine. The submarine and crew departed Groton April 23, 2003, and began the DMP May 19. Originally scheduled for 13 months, PNSY workers and submarine crew worked together to complete the project in less than 12 months. In addition to numerous equipment upgrades, she received a new fire control system that will work in conjunction with the boat's state-of-the-art sonar system. They received new masts and antennas that will allow them to communicate in a much larger bandwidth than in the past. They also upgraded their propulsion plant to improve its efficiency.

December 17, 2005 SSN 760 finished a weeklong interlude in Manama, Bahrain, after docking for crew liberty and mid-deployment maintenance. The port visit marked the midpoint of Annapolis’ six-month deployment as a member of the Theodore Roosevelt Carrier Strike Group, in support of maritime security operations (MSO) in the Mediterranean Sea and the Persian Gulf.

February 16, 2006 USS Annapolis departed Souda Bay, Crete, after a routine port visit. The Groton-based submarine is returning from a scheduled deployment in support of the Global War on Terrorism.

September 6, The Los Angeles-class attack submarine visited its namesake city from Aug. 30 to Sept. 5.

October 6, Rear Adm. Cecil D. Haney relieved Rear Adm. Mark W. Kenny as Commander, Submarine Group Two abord the Annapolis in Groton, Conn.

August 27, 2007 USS Annapolis departed homeport for a scheduled deployment.

November 16, SSN 760 recently arrived in to Mindelo, Cape Verde, for a goodwill port visit. The Annapolis is currently deployed to West and Central Africa to support an ongoing Sixth Fleet effort to improve maritime safety and security. APS is scheduled to bring international training teams to Senegal, Liberia, Ghana, Cameroon, Gabon, and Sao Tome and Principe, and will support more than 20 humanitarian assistance projects in addition to hosting information exchanges and training with regional partner nations.

February 28, 2008 USS Annapolis returned to Naval Submarine Base New London after a six-month underway period. During deployment she visited Rota, Spain; Toulon and Brest, France; Praia, Cape Verde; and Ghana. The Cape Verde visit marked the first visit to Africa outside the Mediterranean by a U.S. submarine.

July 31, Cmdr. Michael O. Brunner relieved Cmdr. Dennis J. McKelvey as commanding officer of the Annapolis.

March 20, 2009 USS Annapolis is currently participating in Ice Exercise (ICEX) 2009, a two-week training exercise about 200 miles from the north coast of Alaska, near Prudhoe Bay, along with researchers from the University of Washington Applied Physics Laboratory and personnel from the Navy Arctic Submarine Laboratory.

October 27, SSN 760 visited the U.S. Naval Academy in Annapolis, Md., Oct. 24-25 as part of the school's homecoming activities.

March 20, 2010 The Los Angeles-class submarine departed Souda Bay, Crete, after a routine port visit.

August 27, USS Annapolis, commanded by Cmdr. John A. Gearhart, returned to Groton after a six-month deployment.

September 30, Capt. William R. Mertz relieved Capt. Robert P. Burke as Commander, Submarine Development Squadron (COMSUBDEVRON) 12, during a change-of-command ceremony aboard the Annapolis at Naval Submarine Base New London.

April 25, 2011 USS Annapolis pulled into Port Everglades, Fla., to participate in the Fleet Week 2011.

January 3, 2012 The Annapolis departed Groton, Conn., for a scheduled deployment.

January 31, SSN 760 recently entered the U.S. 5th Fleet AoR after transiting Suez Canal.