USS Doyle has completed four Mediterranean deployments, two Persian Gulf deployments, and a Standing Naval Forces Atlantic cruise. She has participated in the "Drug War" through Counter-Drug Operations (CDOPS) in the Caribbean Sea, and escorted USS Abraham Lincoln around South America. During the circumnavigation, she set a new speed record for the class by traveling over 16,000 miles in just 1000 hours underway. The frigate returned from the Persian Gulf late in 1996, after conducted an unprecedented 72 queries and 39 boardings in support of the UN embargo against Iraq. Their efforts resulted in the confiscation of more than $3 million of contraband. Additionally, USS Doyle participated in Operation Desert Strike, the only Mayport unit to be involved.

FFG 39 also participated in Fleet Week '98 and also completed UNITAS in November 1998. UNITAS is U.S. Navy's longest-running annual deployment; the word UNITAS is Latin for "unity". This operation promotes a cooperative maritime strategy in the region while supporting the U.S. policy of continued engagement in South America through forward presence. UNITAS 39-98 was conducted with nine South American Navies over a four-month period. The U.S. Task force 138 made up of USS Doyle, USS Moosebrugger (DD 980), USS La Moure County (LST 1194), USS Boston (SSN 703), and USCGC Mohawk, circumnavigated South America in a clockwise direction.

January 19, 2000 USS Doyle departed Mayport en route to a multi-purpose deployment in the eastern Pacific and Caribbean. During this deployment the frigate intercepted a vessel named Rebelde off the coast of Ecuador while conducting routine counter drug operations. After detaining and searching the suspicious vessel, Doyle's embarked U.S. Coast Guard Law Enforcement Detachment (LEDET) discovered six tons of cocaine. Rebelde was taken under tow and delivered to St. Petersburg, Fla.

February 24, 2002 The guided-missile frigate is currently in the Caribbean Sea en route to Columbia, South America, where the ship will join other naval units partcipating in the 43rd annual UNITAS exercise. UNITAS is the largest multi-national naval exercise conducted with naval forcesw from United States and countries from South and Central America.

December 16, 2003 FFG 39 pulled to Souda Bay, Crete, for a routine port visit. The Doyle is part of NATO's Immediate Reaction Force, Standing Naval Force Atlantic (STANAVFORLANT) operating in the eastern Mediterranean under Operation Active Endevaor, NATO's maritime contibution to the fight against international terrorism.

October 6, 2005 USS Doyle and embarked Helicopter Anti-Submarine Squadron (Light) (HSL) 46 Det. 3 returned in September from a successful six-month deployment in the U.S. Southern Command area of operations. The ship’s crew and helicopter detachment performed a variety of operations including counter-narcotics patrols. Under the leadership of Cmdr. Joseph P. Voboril, she was involved in numerous counter-narcotics interdictions, resulting in the seizure of an estimated $315 million in cocaine and 28 alleged narco-terrorists. In addition to interdicting narcotic smuggling, the crew visited the ports of Guantanamo Bay, Cuba; Ochos Rios, Jamaica; Curacao, Netherlands Antilles; Panama City, Panama; and Acapulco, Mexico.

June 30, 2006 The New England fishing community of Gloucester, Mass., welcomed USS Doyle and its crew to celebrate the 79th Annual St. Peter’s Fiesta, June 21-25.

October 9, USS Doyle, commanded by Cmdr. Michael Elliott, is currently docked at the Charlestown Navy Yard during a four-day Columbus Day weekend port visit to the city of Boston.

June 21, 2007 FFG 39 pulled to Conacry, Guinea, for a scheduled port call. The guided-missile frigate is visiting the western African nation to support theater security cooperation and maritime operations in the region.

September 20, The guided-missile frigate recently departed Sao Tome And Principe after a goodwill port visit.

October 3, USS Doyle, four Ghanaian patrol crafts and the newly commissioned South African frigate SAS Mendi (F 148) are currently participating in a visit, board, search and seizure (VBSS) and maritime interdiction operation exercise off the coast of Takoradi, Ghana.

January 25, 2008 The Doyle hosted members of the Defense Advanced Research Project Agency (DARPA) to a day at sea, providing them with a tour of the ship and a demonstration of counter-narcotic capabilities Jan. 16. The guided-missile frigate is currently in its port preparing for an upcoming maintenance availability period.

September 22, USS Doyle, USS Klakring (FFG 42), USS Hawes (FFG 53), USS Mitscher (DDG 57) and USNS Leroy Grumman (T-AO 195) left the U.S. East Coast for Scotland Sept. 19 to participate with allied navies in Joint Warrior, a coalition exercise designed and led by the Joint Tactical Exercise Planning Staff (JTEPS) in the United Kingdom. Joint Warrior will begin in early October and is expected to last approximately two weeks.

May 13, 2009 FFG 39 arrived in Cartagena, Colombia, for a four-day port visit after participating in Operacion Multinacional Alianza with navies from Brazil, Chile, Colombia, and Peru. The Doyle has been deployed since April 19 in support of Southern Seas 2009, a US Southern Command Partnership of the Americas strategy, and focuses on strengthening the relationship in the SOUTHCOM Area of Focus.

May 26, The guided-missile frigate departed La Ceiba, Honduras, after a five-day port call.

May 31, USS Doyle departed Santo Tomas naval base after a three-day visit to Guatemala.

June 11, The Doyle recently arrived in Callao, Peru, for a scheduled port call.

July 8, FFG 39 hosted a closing ceremony in Iquique, Chile, to commemorate the end of a two-week Team Work South (TWS) 2009 exercise.

July 9, USS Doyle arrived in Valparaiso, Chile, for a goodwill port visit.

July 27, The guided-missile frigate recently departed Pisco, Peru.

August 23, The Doyle arrived in Santa Marta, Columbia, for a scheduled port visit.

August 28, USS Doyle arrived in Willemstad, Curacao, for a goodwill port call and to conduct exercice with the Royal Dutch Navy ships.

September 6, FFG 39 departed Chaguaramas, Trinidad and Tobago, after a three-day port visit.

September 11, The guided-missile frigate recently arrived in Colon, Panama, for a goodwill port visit and to take part in multinational training exercise PANAMAX 2009 Sept. 11-22.

November 6, Cmdr. Rolando C. Ramirez relieved Cmdr. John M. Zuzich as the 16th CO of USS Doyle during a change-of-command ceremony held on board the ship.

October 2, 2010 USS Doyle departed Mayport Naval Station for a scheduled counter-illicit trafficking (CIT) deployment in the U.S. Southern Command AoR.

December 2, FFG 39 recently pulled into Vasco Nunez de Balboa Naval Base for a goodwill port visit to Panama City, Panama.

December 6, The Doyle intercepted the 60-foot long fishing vessel Rio Tuira, in the eastern Pacific Ocean, 180 miles off the coast of Panama. A Navy-Coast Guard boarding team recovered approximately 1,100 pounds of cocaine.

December 9, USS Doyle pulled into Golfito, Costa Rica, to take on fuel and supplies.

March 28, 2011 The guided-missile frigate arrived in Naval Station Guantanamo Bay for a routine port call.

April 5, USS Doyle returned to homeport after its last six-month deployment.

July 29, USS Doyle (FFG 39) is decommissioned, after a 28 years of servise, during a ceremony at Naval Station Mayport.