November 4, 2002 USS De Wert (FFG 45) pulled to Souda Bay, Crete for a scheduled port visit. De Wert is currently on a six-month deployment and is part of NATO's Immediate Reaction Force, Standing Naval Force Atlantic (STANAVFORLANT) operating in the eastern Mediterranean under Operation Active Endevaor, NATO's maritime contibution to the fight against international terrorism.

December 20, USS De Wert returned to Mayport, Fla., after completing a six-month deployment, with the USS George Washington (CVN 73) Battle Group, in support of Operation Enduring Freedom.

November 17, 2004 UNITAS Atlantic Phase concluded in Montevideo, Uruguay, after two weeks of seminars and training operations involving more than 2,000 people, 10 ships, two submarines and 11 aircraft from Uruguay, Argentina, Brazil, Spain and the United States.

December 13, 2005 A U.S. Navy SH-60B helicopter from Helicopter Anti-Submarine Squadron (Light) (HSL) 48, homeported in Mayport, Fla., crashed in the eastern Pacific Ocean this morning, while conducting counter-narco terrorism operations in international waters west of Colombia, onboard USS De Wert (FFG 45). Search and rescue efforts for a helicopter and its three crew members have been officially terminated at approximately 6:15 p.m., after exhaustive efforts by U.S. and Colombian Navy air and surface assets.

April 28, 2006 USS De Wert, commanded by Cmdr. M. J. De Clue, returned to Naval Station Mayport after five months patrolling the eastern Pacific Ocean and the Caribbean Sea conducting counter-narco-terrorism operations for U.S. Naval Forces Southern Command. During its 115 days away from home, the frigate traveled nearly 28,000 nautical miles, visited seven cities in the Caribbean, Central America and United States, transited twice through the Panama Canal, and participated in a multinational operation with three other countries. Just before pulling into Mayport for a mid-deployment maintenance period in February, the guided-missile destroyer received national tasking to anchor off the coast of Port Au Prince, Haiti, during that county's elections. It then transited home for two weeks to get the ship back up to full readiness to continue patrolling. In addition to intense training evolutions, FFG 45 participated in a multinational operation, Operation Contra-Ataque with three other countries as part of an ongoing effort to enhance theater security cooperation among nations in the region. The ship also visited ports of Key West, Panama, Guantanamo Bay, Curacao, Aruba and Miami.

May 19, 2007 USS De Wert departed homeport for a scheduled deployment, as part of Surface Strike Group (SSG) 07-2.

June 1, FFG 45 pulled to Aarhus, Denmark, marking the beginning of Baltic Operations (BALTOPS) 2007. This year’s participants include the United States, Denmark, Germany, Russia, the Netherlands, Lithuania, Latvia, France, Poland, Sweden and the United Kingdom. After the exercise, De Wert is scheduled a four-day port visit in Kiel, Germany, where the officers and crew will have the opportunity to experience the annual "Kiel Week." The guided-missile frigate will return to Mayport at the beginning of July, and will deploy later in the month to conduct counter-narcotic operations.

August 23, Coordination between U.S. Coast Guard, Homeland Security Customs and Border Protection, and crews from a U.S. Navy P-3C Orion and USS De wert, resulted in the seizure of an estimated $352 million of cocaine during an interdicted and boarding operation on a self-propelled semi-submersible vessel in the eastern Pacific, Sunday, Aug. 19.

December 10, USS De Wert, commanded by Cmdr. Bill Campbell, recently arrived in Kingston, Jamaica, for a scheduled port call.

March 14, 2008 FFG 45 pulled to Boston for a four-day port visit due to St. Patrick's Day weekend celebration.

May 27, USS De Wert, commanded by Cmdr. Jim Kirk, anchored off the coast of Roatan, Honduras, for a goodwill port call. The ship is currently deployed for counter-illicit trafficking operations in the Caribbean and eastern Pacific.

July 18, While on patrol in the eastern Pacific Ocean, USS De Wert with embarked detachments, Helicopter Anti-Submarine Squadron Light 46 Det. 1, Coast Guard Law Enforcement Detachment (LEDET) 103, and Colombian Navy ship Buenaventura interdicted two go-fast vessels July 11, each carrying over one ton of cocaine.

September 20, The guided-missile frigate intercepted a fishing vessel carrying over three metric tons of cocaine in the eastern Pacific.

October 6, USS De Wert returned to Naval Station Mayport after four-and-a-half month counter-illicit deployment. She departed on May 23 and succeeded in intercepting 8.1 metric tons of cocaine with an estimated wholesale value of $180 million and also visited several ports including Salaverry, Peru; Vasco Nunez de Balboa, Panama; and Curacao, Netherlands Antilles.

October 27, 2009 USS De Wert provided assistance to a Yemeni-flagged dhow Al Faris while the ship was on routine patrol in the Red Sea. The guided-missile frigate is on a scheduled deployment to the U.S. 5th Fleet Area of Responsibility (AoR).

February 25, 2010 FFG 45 recently departed Aqaba, Jordan, after a goodwill port visit.

March 18, USS De Wert returned to Mayport after a six-month underway period in support of counter-piracy and maritime security operations.

May 26, The De Wert pulled into New York City to participate in Fleet Week New York, May 26-June 2.

April 7, 2011 Cmdr. Vince W. Baker relieved Cmdr. Sean G. McLaren as CO of the USS De Wert during a change-of-command ceremony on board the ship at Naval Station Mayport. FFG 45 successfully completed a four-month dry-docking availability at Earl Ship Repair Florida in March.

August 24, The guided-missile frigate pulled into Souda Bay, Grece, for a routine port call. USS De Wert recently departed Mayport for a scheduled deployment in support of counter-piracy and maritime security operations as part of Standing NATO Maritime Group (SNMG) 1.

October 10, USS De Wert responded to a distress call after eleven Somali pirates captured the Italian M/V Montecristo. After RFA Fort Victoria arrived early Tuesday evening, she deployed NATO boarding teams and De Wert communicated with the pirates, forcing them to surrender without violence.

November 26, The De Wert recently pulled into Dar es Salaam, Tanzania, for a scheduled port visit.

December 28, FFG 45 pulled into Port Louis, Mauritius, for a goodwill port visit.