USS Louisville (SSN 724), a Los Angeles-class submarine, was the fourth ship of the U.S. Navy to be named for Louisville, Kentucky. The contract to build her was awarded to the Electric Boat Division of General Dynamics Corporation in Groton, Connecticut on February 11, 1982 and her keel was laid down on September 24, 1984. She was launched on December 14, 1985, sponsored by Mrs. Kinnaird McKee, and commissioned on November 8, 1986, with Capt. Charles E. Ellis in command.

During Operation Desert Shield/Desert Storm USS Louisville made naval history by firing the first submarine launched Tomahawk cruise missile in war. To accomplish this she conducted a 14,000 mile submerged, high speed transit across the Pacific and Indian Oceans to the Red Sea and fired shortly after noon on January 19, 1991.

June 4, 2001 USS Louisville returned home after a six-month western Pacific deployment. The ship visited Yokosuka, Japan; Singapore; Chinhae, ROK; Sasebo, Japan and Gladstone, Australia.

May 24, 2002 Michael E. Jabaley, Jr. relieved Cmdr. Russel t. Janicke as CO of the Louisville during a change-of-command ceremony on board the sub.

September 10, USS Louisville departed Naval Station Pearl Harbor for a scheduled western Pacific deployment.

September 17, The Los Angeles-class attack submarine pulled into Yokosuka, Japan, for a routine port call.

September 27, SSN 724 arrived in Chinhae, Republic of Korea, for a five-day port visit. The ship recently departed Sasebo, Japan, after a brief port call.

October 10, The Louisville pulled again in Chinhae for a another five-day port call after participating in a submarine exercise with the ROKS Lee Chun (SS 062).

October 19, USS Louisville departed Okinawa after a four-day port visit.

November 25, USS Louisville arrived again at Yokosuka for a two-week maintenance period after participating in annual exercise (ANNUALEX), Nov. 12-22.

January 18, 2003 SSN 724 pulled into Apra Harbor, Guam, for a ten-day port visit to get tender support from USS Frank Cable (AS 40).

March 21, Thirty U.S. Navy and coalition warships, including USS Louisville, currently assigned to Naval Forces Central Command launched Tomahawk Land Attack Missiles (TLAMs) during military operations to disarm Iraq.

April 21, USS Louisville arrived in HMAS Stirling at Garden Island, Australia, for a week-long visit to Perth.

May 13, SSN 724 returned to Pearl Harbor after an eight-month deployment in support of Operation Iraqi Freedom.

July 22, The Louisville entered Dry Dock 2 at Pearl Harbor Naval Shipyard for a six-month DSRA. The sub departed dry-dock Nov. 8.

August 13, 2004 Capt. L. David Marquet relieved Capt. William Toti as the 52nd Commander, Submarine Squadron 3, aboard the USS Louisville at Pearl Harbor Naval Station.

USS Louisville, commanded by Cmdr. David Kirk, will depart later in October on a scheduled deployment, with the USS Abraham Lincoln Carrier Strike Group, in the western Pacific.

March 14, 2005 The USS Nimitz Carrier Strike Group, including USS Louisville, is currently participating in a Joint Task Force Exercise (JTFEX) off the coast of southern California through the end of March.

November 16, SSN 724 returned to homeport following a six-month deployment in the western Pacific. During its deployment, the nuclear-powered attack submarine visited Yokosuka, Japan; Brisbane, Australia; Guam and Saipan. In June, she participated in exercise Talisman Sabre off of the coast of Australia and Ship Anti-Submarine Warfare Readiness and Evaluation Measurement (SHAREM) exercises with the Japan Maritime Self Defense Force.

February 10, 2006 USS Louisville returned to Naval Station Pearl Harbor after completing routine trainings in Pacific Ocean.

May 2, USS Louisville, commanded by Cmdr. David Kirk, departed Pearl Harbor for a western Pacific surge deployment. This "surge" deployment is a part of the Fleet Response Plan (FRP), a program developed to change the way ships deploy and to provide the United States with a greater range of naval options, adding an element of flexibility to naval efficiency.

June 28, SSN 724 returned to homeport after completing a two-month underway period.

January 4, 2007 USS Louisville departed Naval Station Pearl Harbor for an 18-month overhaul and modernization period at Portsmouth Naval Shipyard in Kittery, Maine.

January 18, 2009 The Louisville departed Portsmouth Naval Shipyard (PNS) after successfully completing an engineered Overhaul (EOH), well ahead of the chief of naval operations (CNO) mandated completion date of Feb. 24.

January 8, 2010 Cmdr. Lee Sisco relieved Cmdr. John Sager as commanding officer of SSN 724.

April 26, USS Louisville departed Joint Base Pearl Harbor-Hickam for a scheduled western Pacific deployment.

May 7, The Los Angeles-class attack submarine recently arrived at Commander Fleet Activities Yokosuka (CFAY) for a routine port call.

October 29, USS Louisville returned to homeport after a six-month underway period.

February 7, 2012 USS Louisville departed Pearl Harbor for a scheduled western Pacific deployment.