The Los Angeles-improved class attack submarine USS Charlotte is the fourth U.S. Navy ship to bear the name. She was christened on October 3, 1992, at Newport News Shipbuilding by Mrs. Mary McCormack, the ship's sponsor and commisioned on September 16, 1994, at Norfolk, Virginia.

August 25, 2004 USS Charlotte, commanded by Cmdr. Dennis Carpenter, departed Naval Station Pearl Harbor for a western Pacific deployment in support of the Global War on Terrorism.

November 29, 2005 SSN 766 arrived in Norfolk following an historic transit that began in Pearl Harbor, Hawaii, and took the boat under the arctic ice cap. She departed Pearl Harbor Oct. 27 in order to undergo a major Depot Modernization Period (DMP) at the Norfolk Naval Shipyard in Portsmouth, Virginia.

December 7, Cmdr. Bobby J. Pannell relieved Cmdr. Dennis E. Carpenter as CO of USS Charlotte in a ceremony held at Devary Hall, Naval Station Norfolk. Carpenter reported as Charlotte’s commanding officer in April 2003. During his tenure as commanding officer, the nuclear-powered submarine completed two western Pacific and two eastern Pacific deployment.

October 24, 2007 USS Charlotte returned to Pearl Harbor after having completed a two-year Depot Modernization Period at NNSY.

April 29, 2008 Cmdr. Butch Dollaga relieved Cmdr. Bobby Pannel as CO of the Charlotte during a change-of-command ceremony at Pearl Harbor Naval Station.

September 12, Rear Adm. Douglas McAneny relieved Rear Adm. Joe Walsh as Commander, Submarine Force Pacific Fleet, during a ceremony on board the USS Charlotte.

January 26, 2009 USS Charlotte departed homeport for a scheduled western Pacific deployment.

April 16, 2010 Cmdr. Richard S. Young relieved Cmdr. Butch Dollaga as commanding officer of the USS Charlotte.

December 1, SSN 766 departed Joint Base Pearl Harbor-Hickam for a scheduled deployment in the U.S. 7th Fleet Area of Responsibility (AoR).

May 31, 2011 USS Charlotte returned home after a six-month western Pacific deployment.