SSN 769 is the third ship of the U.S. Navy to be named for Toledo, Ohio. The contract to build her was awarded to Newport News Shipbuilding and Dry Dock Company in Newport News, Virginia on June 10, 1988 and her keel was laid down on May 6, 1991. She was launched on August 28, 1993, sponsored by Mrs. Sabra Smith, and commissioned on February 24, 1995, with Cmdr. Jack Loye III in command.

February 16, 2002 USS Toledo departed homeport for a six-month deployment, with the USS John F. Kennedy (CV 67) Battle Group, in support of Operation Enduring Freedom. The sub returned to Groton in August or September.

March 21, 2003 Thirty U.S. Navy and coalition warships, including USS Toledo, currently assigned to Naval Forces Central Command launched Tomahawk Land Attack Missiles (TLAMs) during military operations to disarm Iraq.

April 15, SSN 769, commanded by Cmdr. Michael T. Poirier, returned to Naval Submarine Base New London after rapid response, two-month, wartime patrol in support of Operation Iraqi Freedom. Deployed, from Feb. 10, to the Mediterranean Sea and the Red Sea, she conducted strike operations into Iraq, launching several Tomahawk cruise missiles during the patrol.

December 7, 2004 USS Toledo returned to homeport after a six-month deployment in the Persian Gulf with the John F. Kennedy carrier strike group that included port calls in Crete, Dubai, and Bahrain. Her route home from Bahrain was unusual, rounding the Cape of Good Hope rather than using the Suez Canal. Once back in the North Atlantic, she was diverted for a classified drug interdiction mission with the Joint Interagency Task Force–South in the Caribbean Sea.

April 25, 2005 The nuclear-powered attack submarine pulled to Fort Lauderdale, Fla., to participate in Fleet Week 2005.

January 31, 2006 SSN 769 departed Groton, Conn., for a scheduled deployment.

April 8, The Toledo departed the port of Jebel Ali, United Arab Emirates, after a brief visit. She is currently operating in the U.S. 5th Fleet area of operations in support of maritime security operations (MSO).

August 10, Cmdr. Goldman relieved Cmdr. Schnieder as commanding officer of USS Toledo.

January 11, 2007 USS Toledo departed Submarine Base New London for Newport News Shipyard where it will undergo a routine Depot Modernization Period (DMP) during which time it will be temporarily homeported in Norfolk.

February 21, 2009 Northrop Grumman Shipbuilding redelivered the Groton-based submarine to the Navy after the ship successfully completed sea trials. The two-year work included upgrading the Toledo's sonar, combat and weapons systems, and performing maintenance on the living areas and propulsion systems.

March 5, Cmdr. Douglas Reckamp relieved Cmdr. Howard Goldman as CO of the Toledo during a change-of-command ceremony aboard the submarine in Norfolk.

March 13, USS Toledo returned to Groton, Connecticut, after a 26-month depot modernization period.

April 26, SSN 769 pulled to Port Canaveral, Fla., to embark members of the media enroute to Port Everglades for a Fleet Week celebration.

July 21, The Toledo crew members recently discovered a 21-inch crack in the topside hull, just before underway for local operations, as well as a corresponding one-inch crack in the pressure hull that would have leaked water if the ship was submerged. The U.S. Navy is currently conducting additional tests to determine the extent of the crack and the proper procedures to repair it.

February 5, 2010 USS Toledo departed Magnetic Silencing Facility, at the Trident Refit Facility at Submarine Base Kings Bay, after completing a four-day electromagnetic trial period.